Paroxysmal nocturnal hemoglobinuria

A rare acquired hematologic disorder characterized by hemolytic anemia, dark-colored urine due to the release of hemoglobin in the blood, and thrombosis. The episodes of hemolysis tend to occur at night. It is caused by a somatic mutation in the glycosylphosphatidylinositol biosynthesis gene.

Disease Alternative Name

pnh
paroxysmal hemoglobinuria
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