Familial adenomatous polyposis
An autosomal dominant disorder, characterized by the presence of multiple adenomas in the colon and rectum. It is caused by a germline mutation in the adenomatous polyposis coli (APC) gene which is located on the long arm of chromosome 5. The adenomas are most often tubular, and they have the tendency to progress to adenocarcinoma. They can occur throughout the colon, but they tend to concentrate in the rectum and sigmoid colon. The colorectal adenomas are detected during endoscopic examination between the age of 10 and 20 years. The adenomas increase in size and numbers with age, and there is usually progression of one or more adenomas to adenocarcinoma. The mean age of development of adenocarcinoma is about 40 years. Signs include rectal bleeding and mucousy diarrhea.
Disease Alternative Name
If they undergo loss of function mutation, they lead to cancers
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Recent Cases of Familial adenomatous polyposis
Browse recently discussed Familial adenomatous polyposis cases by specialistsTop Cases of Familial adenomatous polyposis
Selected by editors, top cases are known for unique problem or best solutionTop Familial adenomatous polyposis Doctors on Curofy
Top doctors who continously share their opinions on Familial adenomatous polyposisPrince Mohammed Bin Nasser Specialist Hospital
Pathologist, Medical Lab Director
Rangaraya Medical College, NTR UHS
MD (Pathology)
Rajkot Cancer Society
Pathologist
Geetanjali Medical College & Hospital, Geetanjali Cancer Center
MD Pathology
Central Hospital,Dhuliyan
MO
Calcutta National Medical College and Hospital
MBBS
Worked at Jalna.Latur. and Now Mumbai.
Consulting Surgeon
Consulting Surgeon.
M.S.,FICS,FAIS. Sr. Surgeon.
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