Chronic granulomatous disease
A rare genetic disorder with a predominantly X-linked recessive pattern of inheritance resulting in impaired phagocytic clearance of bacteria and fungi. It is caused by a defect in the phagocytic NADPH oxidase (phox) complex. The phagocytes can engulf pathogens but are unable to produce the microbicidal precursors needed to destroy them. Clinical signs of severe disease present in childhood with milder forms later in life. They include recurrent infection especially pneumonia, cervical lymphadenopathy and hepatosplenomegaly. The clinical course includes the appearance of granulomata in the skin and gastrointestinal or genitourinary tracts. The clinical prognosis is dependent on effectively treating and preventing infection.
Disease Alternative Name
Recent Cases of Chronic granulomatous disease
Browse recently discussed Chronic granulomatous disease cases by specialistsRhinoscleroma - Chronic Granulomatous disease
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Top Cases of Chronic granulomatous disease
Selected by editors, top cases are known for unique problem or best solutionTop Chronic granulomatous disease Doctors on Curofy
Top doctors who continously share their opinions on Chronic granulomatous diseaseSuper Specialist in Reproductive Endocrinology

Konaseema Inst. of Medical Sciences Research Foundation
Campus Ambassasor for Smarc 2018
Konaseema Inst. of Medical Sciences Research Foundation
MBBS

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PGIMER, Chandigarh
MD

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A case of Abdominal epilepsy *Chief Complaints* Loss of consciousness one episode Pain abdomen and loose stools *History* A female patient 25 year old came to the OPD with complaints of loss of consciousness after an episode pf loose stools prior to which she had severe crampy abdominal pain. Symptoms lasted for about 3-4 min witnessed by her mother.No h/o tonic clonic movements. No h/o fever headache giddiness, visual disturbance or ENT symptoms No post episode headache limb weakness Known case of IBS on diet.Hypothyroid on 25 mcg Thyronorm OD.. *Vitals* Normal *Investigations* EEG normal.MRI brain small nodular subependymal heterotopia adjacent to the atrium of right lateral ventricle. *Physical Examination* Nothing significant *Diagnosis* Abdominal Epilepsy *Management* Started on Tab Carbamazepine 300 mg incremental dosage
Dr. Naga Tanooj0 Like2 Answers - Login to View the image
CHOICE OF MECHANICAL VENTILATION
Dr. Prashant Vedwan1 Like1 Answer
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