Chronic granulomatous disease
A rare genetic disorder with a predominantly X-linked recessive pattern of inheritance resulting in impaired phagocytic clearance of bacteria and fungi. It is caused by a defect in the phagocytic NADPH oxidase (phox) complex. The phagocytes can engulf pathogens but are unable to produce the microbicidal precursors needed to destroy them. Clinical signs of severe disease present in childhood with milder forms later in life. They include recurrent infection especially pneumonia, cervical lymphadenopathy and hepatosplenomegaly. The clinical course includes the appearance of granulomata in the skin and gastrointestinal or genitourinary tracts. The clinical prognosis is dependent on effectively treating and preventing infection.
Disease Alternative Name
Recent Cases of Chronic granulomatous disease
Browse recently discussed Chronic granulomatous disease cases by specialistsRhinoscleroma - Chronic Granulomatous disease
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Top Cases of Chronic granulomatous disease
Selected by editors, top cases are known for unique problem or best solutionTop Chronic granulomatous disease Doctors on Curofy
Top doctors who continously share their opinions on Chronic granulomatous diseaseSuper Specialist in Reproductive Endocrinology
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PGIMER, Chandigarh
MD
Self Emploid(private Clinic)
Morbi
Shri M P Shah Medical College Jamnagar
M B B S
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