50 yr male h/o multiple swellings over body since 1 ur, insidious onset, even present in orbit, fnac done on 2 nodes shows polygonal cells with eccentric nucleus, binucleate cells, nuclear margins irregular, cleaved, cytoplasm has vacuoles, kindly comment, his CBS is within normal except for HB 12.8

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Plasma cell dyscrasia. Multiple myeloma with metastatic deposits.

DDs : •Blastic Plasmacytoid Dendritic Cell Neoplasm. Advised IHC with a Panel of CD4,CD56,CD123 & TCL1. •Multiple Myeloma with Multiple Cutaneous Myeloma Deposits.Advised correlation with Serum Protein Electophoresis & Skeletal Rafiography,BMA,FCM,IHC with CD38,CD138..

Plasmacytoma

Plasmacytoma D/d plasmacytoid lymphoma/multiple myeloma

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Possibly,Plasma cell neoplasm -Biopsy and IHC for needful.

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Plasmacytoid lymphoma/plasamacytoma

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Dd plasmacytoma/myeloma deposits Plasmacytoid lymphoma Disseminated malignancy..mets

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Plasmacytoma/Myeloma Adv BM study and M band electrophoresis with biopsy work up IHC

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plasmacytoma

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Sug. Clinical correlation Bone marrow study Skeletal survey S proein electrophoresis bx..ihc

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